WebJul 17, 1998 · The enantioselective synthesis of the trans-2,6-dialkylpiperidine alkaloids (2R,6R)-lupetidine and (2R,6R)-solenopsin A from 6-methyl-2-piperidone 1 is described. … WebAbstract. The fire ant venom alkaloid (±)-solenopsin A was prepared in 4 steps (34%) starting from the N-phenyl-2-undecyl piperidine (1c).The key step in this synthesis involved the dearomatization of the phenyl group of N-phenyl-2-methyl-6-undecyl-piperidine (9c), which was carried out under Birch conditions.
Synthesis of (+)-solenopsin via Pd-catalyzed N -alkylation and ...
WebTherefore, solenopsin and related compounds have been the target of organic synthesis from which pure compounds can be produced for individual study. Originally synthesized in 1993, several groups have designed novel and creative methods of synthesizing enantiopure solenopsin and other alkaloidal components of ant venom. WebJul 17, 1998 · The enantioselective synthesis of the trans-2,6-dialkylpiperidine alkaloids (2R,6R)-lupetidine and (2R,6R)-solenopsin A from 6-methyl-2-piperidone 1 is described. The key step of this synthesis consists of the addition of a dialkylcopper derivative to the thioimidate salt 3 followed by sodium borohydride reduction of the resulting iminium salt. how do i apply for the aged pension in nsw
ChemInform Abstract: Synthesis of Enantiomerically Pure
WebJan 20, 2024 · Synthesis of (+)-solenopsin, a 2,6-disubstituted piperidine alkaloid, isolated from fire ants (Solenopsis), was achieved. Stereoselective construction of trans -2,6 … WebApr 30, 1993 · Enantiomerically pure solenopsin A (1) was prepared in 11 steps from L-aspartic acid (3) in an ... No. 19, 2911-2914.1993 O0409/'93 $6.00 + .00 Printed in Great Britain Pergsmwt Press Ltd An Enantiospecific Synthesis of Solenopsin A Charles W. Jefford' and Jian Bo Wang Department of Organic Chemistry, University of Geneva 1211 ... WebJan 1, 2008 · An enantioselective route to solenopsin B (1), the major saturated component of the alkaloid mixture isolated from the venom of the fire ant, Solenopsis invicta, is reported. how do i apply for the ertc