WitrynaAfter IV administration, nalbuphine's onset of action is 2 to 3 minutes. Its duration of action is slightly longer than that of morphine (approximately 3 to 6 hours). ... Nalbuphine HCl was rapidly cleared after both IM and IV dosing of 12.5 mg/kg to Hispaniolan Amazon parrots and had excellent bioavailability following IM administration, ... WitrynaCONTRAINDICATIONS. Nalbuphine Hydrochloride Injection is contraindicated in patients with: Significant respiratory depression [see WARNINGS] Acute or severe …
nalbuphine hydrochloride injection - Pfizer Medical Information
Nalbuphine hydrochloride is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series. It is chemically related to both the widely used opioid antagonist, naloxone, and the potent opioid analgesic, oxymorphone. Chemically Nalbuphine hydrochloride is 17-(cyclobutylmethyl)-4,5α … Zobacz więcej Mechanism of Action Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors. Pharmacodynamics … Zobacz więcej Nalbuphine Hydrochloride Injection is indicated for the management of pain severe enough to require an opioid analgesic and … Zobacz więcej Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as … Zobacz więcej Nalbuphine Hydrochloride Injection is contraindicated in patients with: 1. Significant respiratory depression [see WARNINGS] 2. Acute or severe bronchial asthma in an unmonitored setting or in the absence of … Zobacz więcej WitrynaProduct Name: Nalbuphine Hydrochloride Injection 5 performed in rats by subcutaneous administration of nalbuphine up to 100 mg/kg/day (590 mg/m2/day), and in rabbits by intravenous administration of nalbuphine up to 32 mg/kg/day (378 mg/m2/day). The results did not reveal evidence of developmental toxicity, including … discretionary and non-discretionary spending
Pharmacokinetics of Nalbuphine Injection - Full Text View ...
WitrynaNalbuphine is a potent analgesic. Its analgesic potency is essentially equivalent to morphine. It binds to mu, kappa, and delta opioid receptors. Nalbuphine is … WitrynaIndications and Dosage. Intravenous. Adjunct in balanced anaesthesia. Adult: Induction: 0.3-3 mg/kg over 10-15 min. Maintenance: 0.25-0.5 mg/kg as single admin if … WitrynaNalbuphine injection is used is used to relieve moderate to severe pain. It is also used with other medications and anesthesic agents before, during, and after surgery and … discretionary ang