WebNeil J. Mckenna, David D. Moore, in Endocrinology (Sixth Edition), 2010 HNF-4. Hepatocyte nuclear factor4α (HNF-4α) is another orphan originally identified based on its ability to recognize specific sites, in this case in various promoters active in the liver. 42 It binds these elements as a homodimer. Additional studies revealed that it is also … Web15 mrt. 2024 · Nonalcoholic fatty liver disease is worldwide pandemic encompassing nonalcoholic hepatosteatosis (NAFLD), nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Even the simple fatty liver is associated with increased 71% of liver-specific and overall mortality [1].
Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon ...
Web15 nov. 2024 · Hepatocyte-specific deletion of Trib1 increased plasma lipids and lipoprotein levels. To assess the hepatic effects of Trib1 deletion on LDL-C, we injected Trib1 fl/fl mice with AAV8-TBG-Cre to induce hepatocyte-specific deletion of Trib1 (Trib1 Δ hep) and compared them with control mice WT for Trib1 (Trib1 WT) receiving the same AAV … blackpool youth district league
Liver endothelial cells promote LDL-R expression and the …
Web17 jul. 2024 · Lipid accumulation in hepatocytes are implicated in the pathogenesis of chronic liver injury. CD36 is known to mediate long-chain fatty acid (LCFA) uptake and lipid metabolism. However, it is unclear whether LCFA directly promotes hepatocyte activation and the involved mechanisms have not been fully clarified. Methods Web29 jul. 2024 · Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, … Web21 jul. 2024 · Lipoviroparticles can enter hepatocytes via multiple receptors including the hepatocyte LDL receptor (which may also facilitate the replication step of the HCV cycle ) and utilizes cell surface … blackpool youth football tournament