WebInternational Journal of Molecular Sciences (Aug 2016) . CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis WebThe synthetic peptide, with CTHRSSVVC sequence (PepA), mimics the CD163 and TNF-α tripeptide “RSS” motif and binds to atheromatous plaques in carotid biopsies of human patients, spleen tissues, and a low-density lipoprotein receptor knockout (LDLr−/−) mouse model of atherosclerosis. CD163 receptor is present on monocytes, macrophages ...
CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target …
WebMay 8, 2024 · Silva et al. conducted a study using a novel peptide, CTHRSSVVC, labeled with indium-111 ([111 In]DOTA-CTHRSSVVC) and showed high tracer uptake in the atheroma of low-density protein receptor-deficient mice ex vivo (Silva et al. 2016). Besides being a promising candidate for CD163 receptor imaging with single-photon emission … WebDevelopment of [F-18]AlF-NODA-CTHRSSVVC for imaging M2 macrophages with PET. European Journal of Nuclear Medicine and Molecular Imaging. 2024 Sep;47(SUPPL 1):S163-S163. Powered by Pure, Scopus & Elsevier Fingerprint Engine ... nova bsa whoosh
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WebTherefore, we evaluated novel PET tracers for CD163 receptor and arginase for imaging of M2-like macrophages. The CD163-tracer NODA-MP-C6-CTHRSSVVC was labeled with aluminum [18F]fluoride and showed approximately 50% of specific receptor-mediated binding in vitro using human CD163-expressing tissue homogenates and enabled clear … WebApr 13, 2024 · Ssc5d mRNA levels were significantly elevated in MI and TAC mouse models. (A,B) The relative mRNA expression of Ssc5d after TAC (1 and 4 W) (n = 6) and MI (14 and 28 days) (n = 5-7) surgery. WebPreparo e avaliação do conjugado NOTA-CTHRSSVVC radiomarcado com [68Ga]gálio e [18F]AlF nova brewery imperial beach