WebAbstract. Heparin cofactor II (HCII) is a serine protease inhibitor (serpin) found in high concentrations in human plasma. Despite its discovery >30 years ago, its physiological function is still poorly understood. It is known to inhibit thrombin, the predominant coagulation protease, and HCII-thrombin complexes have been found in plasma, yet ...
In vitro reversal of direct factor Xa inhibitors: Direct comparison of ...
WebMar 1, 2016 · Clotting factor concentrates are clinically widely used drugs for the … WebHeparin cofactor II is a glycoprotein that belongs to the serine protease inhibitor family. 6 Heparin cofactor II, also known as heparin cofactor A or dermatan sulfate cofactor, has a molecular weight of approximately 65 kilodaltons and has a plasma concentration of 9 mg/dL. Heparin cofactor II is synthesized by the liver and has a plasma half-life of 60 … emergency abscessed tooth
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WebHeparin cofactor II (HCII) is a 66-kDa plasma glycoprotein that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Clones comprising the entire HCII gene were isolated from a human leukocyte genomic library in EMBL-3 λ phage. The sequence of the gene was determined on both strands of DNA (15 849 bp) and included 1749 bp ... WebMar 1, 2016 · Heparin was removed from clotting factor concentrates by using the anionic exchange resin ecteola cellulose (coarse grade; Sigma-Aldrich, St Louis, MA, USA). Pilot experiments revealed that 1.25 mg ecteola cellulose was required to neutralize 1 IU unfractionated heparin (from porcine mucosa, NIBSC). WebHeparin cofactor II is found in plasma and rapidly blocks thrombin in the presence of … emergency absence